Danielle S Ahn, MD

Pediatric Critical Care Medicine
More specialties
Treats Children
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Dr. Ahn's clinical work is in the pediatric intensive care unit, where many of the sickest children in the hospital are suffering the consequences of respiratory failure. Care for these children has changed very little over the past few decades and is limited to supportive care such as antibiotics, ventilator support and nutrition. Her experience caring for these children has compelled Dr. Ahn to investigate the mechanisms that underly the severe respiratory disease that we see in children and the sometimes abnormal and devastating response to rather common pathogens.

To accomplish this goal, Dr. Ahn has devoted her research time to the study of innate immune cell recruitment and related signaling pathways in response to multi-drug resistant bacteria in pulmonary infections. Under the mentorship of Dr. Alice Prince, Dr. Ahn has utilized in vivo and in vitro models of infection and immunologic and molecular biology techiniques to ask hypothesis-driven questions. This is all in an effort to identify potential therapeutic targets to help the immune system overcome these bacteria that have gained antimicrobial resistance. This effort is very important with increasing morbidity and mortality in the immunocompromised and critically ill.

Areas of Expertise / Conditions Treated

  • Pediatric Critical Care Specialist

Academic Appointments

  • Assistant Professor of Pediatrics

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center


  • Spanish


  • Female

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Credentials & Experience

Education & Training

  • MD, University of Virginia School of Medicine
  • Residency: Bellevue Hospital Center
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

Committees, Societies, Councils

New York Society for Pediatric Critical Care Medicine

American Academy of Pediatrics

American Thoracic Society

Society of Critical Care Medicine

Society for Peditric Research

Board Certifications

  • Pediatrics
  • Pediatric Critical Care Medicine


Dr. Ahn has devoted herresearch time to the study of innate immune cell recruitment and related signaling pathways in response to multi-drug resistant bacteria in pulmonary infections. Identifying therapies to improve the host immune system response to illness due to bacterial infections has become even more important with the rise of antibiotic resistance and high morbidity and mortality in our immunocompromised and critically ill patients. To understand the molecular biology and immunology of these pulmonary infections, Dr. Ahn has utilized animal and in vitro cell culture models, cytokine analysis, multi-color flow cytometry, immunohistochemical staining, and imaging by confocal microscopy. She has expanded the skills she developed under the guidance of Dr. Alice Prince, from her original studies in T-cell and macrophage biology in response to MRSA to the role of resident and recruited macrophages and monocytes in response to another multi-drug resistant pathogen, Klebsiella pneumoniae.