Unraveling the Enigma of Immune Disease and Allergic Disorders
Allergy, Immunology, and Rheumatology
The Division of Allergy, Immunology, and Rheumatology includes some of the best-known names in pediatric allergy, immune-related, or autoimmune-related diseases. These leaders in the field have created new laboratories and research programs while providing expert diagnoses and care to children and families, many of whom have long sought an identification of a chronic illness.
NewYork-Presbyterian Morgan Stanley Children’s Hospital now serves as a referral center for other children’s hospitals and has the expertise and resources to diagnose and care for the most complex patients. Our physicians share their knowledge as chairs of numerous national committees, create and participate in patient registries, author innumerable publications, and participate on editorial and scientific advisory boards.
In 2023:
- Joshua Milner, MD, launched a major regional program, New York ROYAL, to centralize systematic evaluation of rare immune disorders in a multidisciplinary fashion, and to provide state of the art clinical and research diagnosis and practical management resources. Emerging from the New York Regional Primary Immune Disorder consortium of physicians, scientists, industry partners, the Jeffrey Modell Foundation and others. NY Royal was awarded an NIAID R24 Resource grant to fund the research diagnostic component of this initiative.
- The Division welcomed Allie Antosy, PhD, a clinical psychologist, jointly appointed with the Division of Gastroenterology, Hepatology, and Nutrition. Dr. Antosy is establishing a transformative clinical and research program focused on integrated known and novel behavioral health modalities into the standard care of allergic, immunologic, and rheumatologic disorders.
- Joel Brooks, DO, established an antibiotic allergy delabeling clinic, a critical component of antibiotic stewardship, which rapidly improves access to the most appropriate antibiotic choices by safely demonstrating the lack of allergic reactions in the overwhelming majority of patients previously labeled with the given antibiotic allergy.
- Joyce Yu, MD, established a chemotherapy desensitization clinic, a very complicated but critical process to provide access to life-saving cancer treatments to patients who could otherwise not tolerate therapies due to allergic reactions.
New Appointments
Promotions
- Emily Mace, PhD
- Associate Professor of Pediatrics
Honors and Awards
- Alexandra Antosy, PhD
- Presenter at the annual Researching Esophageal Atresia for Children’s Health (REACH) symposium
- Presented a poster at the annual NASPGHAN conference
- Ramsay Fuleihan, MD
- Invited Speaker at the 12th International “Update in Pediatric Immunology” conference
- Presenter at the American Academy of Allergy Asthma and Immunology annual meeting, “Update on XLA-United States Immunodeficiency Network (USIDNET) Registry Report”
- Invited speaker at the 2023 second Qatar Allergy & Immunology Conference: “Immune Dysregulation”
- Associate Editor, Frontiers in Immunology
- Emily Mace, PhD
- Recipient of the Whitman Fellowship Award through the Woods Hole Marine Biological Laboratory
- Invited speaker at the Society for Natural Immunity “NK2023” meeting in Oslo, Norway
- Invited speaker at the Clinical Immunology Society meeting
- Proposal titled “Generation of novel tools to study cell cycle from pluripotency to differentiation” was selected for a seed fund award from the Columbia Stem Cell Initiative
- Mervat Nassef, MD
- Elected to serve on the ACAAI Board of Regents
- Castle Connolly Exceptional Women in Medicine and Top Doctors
- New York Times Magazine Super Doctors
- Jordan Orange, MD, PhD
- Awarded the inaugural 2023 Irving Cancer Drug Discovery Program (ICDDP) Award for research titled, "Optimizing cell therapy for solid tumors by hardwiring cytotoxic cell lytic granule dispersion via genome wide and small molecule screens.
Major Grants
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Genetic, Immunologic and Mechanistic Basis of Human NK Cell Deficiency. NIH/NIAID (RO1 AI120989). PI: Jordan Orange, MD, PhD
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Directing Function at the Natural Killer Cell Secretory Immunological Synapse. NIH/NIAID (R01 AI067946). PI: Jordan Orange, MD, PhD
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Optimizing cell therapy for solid tumors by hardwiring cytotoxic cell lytic granule dispersion via genome wide and small molecule screens. Herbert Irving Comprehensive Cancer Center (HICCC), Irving Cancer Drug Discovery Program. Lead Investigator: Jordan Orange, MD, PhD
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Defining the functional role of CD56 on human natural killer cells. NIH-National Institute of General Medical Sciences (R01GM148504). PI: Emily Mace
- New York Regional Inborn Errors of Immunity Resource Initiative League (NY-ROYAL). NIH (R24AI167802). Co-PI: Joshua Milner
- Establishing the contributions of monogenic etiologies to hidradenitis suppurativa pathogenesis. NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR080796). Co-I: Joshua Milner
- Mechanistic Elucidation of Pathogenic CBM Complex Mutations Associated with Atopic Disease. NIH (R01AI168295-01A1). Co-I: Joshua Milner
Selected Publications
- Qin Y, Mace EM, Barton JP. An inference model gives insights into innate immune adaptation and repertoire diversity. Proc Natl Acad Sci USA. 2023 Sep 19;120(38):e2305859120. Epub 2023 Sep 11.
- Correa-Jimenez O, Restrepo-Gualteros S, Nino G, Cunningham-Rundles C, Sullivan KE, Fuleihan RL, Gutierrez MJ. Respiratory Comorbidities Associated with Bronchiectasis in Patients with Common Variable Immunodeficiency in the USIDNET Registry. Journal of Clinical Immunology. 2023;43(8):2208-20. Epub 2023/11/07.
- O'Toole D, Groth D, Wright H, Bonilla FA, Cunningham-Rundles C, Sullivan KE, Ochs HD, Marsh RA, Feuille E, Fuleihan RL. Outcomes among racial and ethnic minority groups with X-linked agammaglobulinemia from the USIDNET registry. J Allergy Clin Immunol Pract. 2023.
- Gunderman L, Brown J, Chaudhury S, O'Gorman M, Fuleihan R, Khanolkar A, Ahmed A. Co-Occurring X-Linked Agammaglobulinemia and X-Linked Chronic Granulomatous Disease: Two Isolated Pathogenic Variants in One Patient. Biomedicines. 2023;11(3). Epub 20230321.
- Stotter BR, Cody E, Gu H, Daga A, Greenbaum LA, Duong MD, Mazo A, Goilav B, Boneparth A, Kallash M, Zeid A, Seeherunvong W, Scobell RR, Alhamoud I, Carter CE, Shah S, Straatmann CE, Dixon BP, Cooper JC, Nelson RD, Levy DM, Brunner HI, Verghese PS, Wenderfer SE. Acute kidney injury requiring kidney replacement therapy in childhood lupus nephritis: a cohort study of the Pediatric Nephrology Research Consortium and Childhood Arthritis and Rheumatology Research Alliance. Pediatr Nephrol. 2023 May; 38(5):1653-1665.
- DiCola K, Antosy A, Steinberg D. (2023). Back to School: Parental Concerns of Children with Hematological and Oncological Conditions During the COVID-19 Pandemic. Continuity in Education. (4)126-138. 10.5334/cie.92.
- O’Shea D, Schmoke N, Porigow C, Murray LP, Chung WK, Kattan M, Jang M, Antosy A, Middlesworth W, Khlevner J. Recent Advances in the Genetic Pathogenesis, Diagnosis, and Management of Esophageal Atresia and Tracheoesophageal Fistula: A Review. Journal of Pediatric Gastroenterology and Nutrition. 2023;77(6):703-712.
- K Baysac, G Sun, H Nakano, EG Schmitz, C Fisher, AC Bailey, PLCG2-Immune Dysregulation Working Group, E Mace, JD Milner, M. Ombrello. PLCG2 associated antibody deficiency and immune dysregulation (PLAID) comprises broad and distinct clinical presentations related to functional classes of genetic variants. J Allergy Clin Immunol. S0091-6749(23)01200-9 2023.
- Leiding JW, Vogel TP, Santarlas VGJ, Mhaskar R, … Cooper MA, Milner JD, Forbes Satter LR. Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome. J Allergy Clin Immunol. 2023;151(4):1081-95.
- Son A, Meylan F, Gomez-Rodriguez J, Kaul Z, Sylvester M, Falduto GH, Vazquez E, Haque T, Kitakule MM, Wang C, Manthiram K, Qi CF, Cheng J, Gurram RK, Zhu J, Schwartzberg P, Milner JD, Frischmeyer-Guerrerio PA, Schwartz DM. Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation. Nat Immunol. 2023 Jun;24(6):1036-1048.
Highlights
Joyce Yu, MD, Shares her Advice for Surviving Allergy Season
Pediatric allergist Joyce Yu, MD contributed to stories from a number of major news outlets, including the New York Times and Wall Street Journal, offering helpful advice about navigating allergy season.
Read the Wall Street Journal Article
Food Allergies and Food Sensitivities: The Latest in Prevention, Diagnosis, and Treatment
Pediatric allergist Joel Brooks, DO, joined Jacqueline Jossen, MD, pediatric gastroenterologist, and Sally Dorfzaun, MS, RD, CDN, pediatric dietitian, for a conversation exploring food allergies and food sensitivities.