Basic and translational science

Dr. Vadim Ten (Director of Neonatal Research) leads NIH-funded laboratory of translational neonatology. Using mouse models of neonatal diseases: chronic lung disease (CLD), perinatal hypoxic-ischemic brain injury and diffuse white matter injury (WMI), his team determines mechanistic role of mitochondrial dysfunction in diseases of developmental failure in premature infants; arrest of alveolarization in CLD and axonal myelination in diffuse WMI. Translational research is focused on discoveries of novel mitochondria-targeted neuroprotective compounds against cerebral ischemia-reperfusion injury in the developing brain.

Dr. Thomas Hooven’s research is focused on understanding the biology of group B streptococcus with the aim of identifying new vaccine targets. His research uses mouse models of ascending chorioamnionitis and sepsis (both early- and late-onset).

Dr. Amelie Collins studies developmental aspects of the unique biology of fetal and neonatal multipotent progenitor cells which could play a key role in the aberrant hematological responses of preterm and term infants. Improvements in our understanding of their specific biology could lead to new avenues of diagnosis and therapy.