Kernie Lab

Publications

  • Motelow JE, Lippa NC, Hostyk J, Feldman E, Nelligan M, Ren Z, Alkelai A, Milner JD, Gharavi AG, Tang Y, Goldstein DB, Kernie S.G. Risk Variants in the Exomes of Children With Critical Illness. JAMA Netw Open. 2022 Oct 3;5(10):e2239122. doi: 10.1001/jamanetworkopen.2022.39122. PMID: 36306130; PMCID: PMC9617179.

  • McGowan JC, Ladner LR, Shubeck CX, Tapia J, LaGamma CT, Anqueira-González A, DeFrancesco A, Chen BK, Hunsberger HC, Sydnor EJ, Logan RW, Yu TS, Kernie S.G., Denny CA. Traumatic brain injury-induced fear generalization in mice involves hippocampal memory trace dysfunction and is alleviated by (R,S)-ketamine. Biol Psychiatry. 2023 Jul 7:S0006-3223(23)01404-X. doi: 10.1016/j.biopsych.2023.06.030. Epub ahead of print. PMID: 37423591.

  • Chintamen S, Gaur P, Vo N, Bradshaw E, Menon V, Kernie S. G. Unique Microglial Transcriptomic Signature within the Hippocampal Neurogenic Niche. bioRxiv 2021 Aug 29;457876; doi: 10.1101/2021.08.29.457876. 

  • Yu TS, Tensaouti Y, Stephanz E, Chintamen S, Rafikian E, Yang M, Kernie S. G. Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice. Commun Biol 4, 1303 2021 Nov 18;4:1303. doi:10.1038/s42003-021-02841-4 

  • Tensaouti Y, Stephanz EP, Yu TS, Kernie S.G. ApoE Regulates the Development of Adult Newborn Hippocampal Neurons. eNeuro. 2018 Aug 2;5(4):ENEURO.0155-18.2018. doi: 10.1523/ENEURO.0155-18.2018. PMID: 30079373; PMCID: PMC6072333.

  • Yu TS, Tensaouti Y, Bagha ZM, Davidson R, Kim A, Kernie S.G. Adult newborn neurons interfere with fear discrimination in a protocol-dependent manner. Brain Behav. 2017 Aug 2;7(9):e00796. doi: 10.1002/brb3.796. PMID: 28948089; PMCID: PMC5607558.

  • Hong S, Washington PM, Kim A, Yang CP, Yu TS, Kernie S.G. Apolipoprotein E Regulates Injury-Induced Activation of Hippocampal Neural Stem and Progenitor Cells. J Neurotrauma. 2016 Feb 15;33(4):362-74. doi: 10.1089/neu.2014.3860. Epub 2015 Jun 11. PMID: 25905575; PMCID: PMC4761847.

  • Cho KO, Lybrand ZR, Ito N, Brulet R, Tafacory F, Zhang L, Good L, Ure K, Kernie S.G., Birnbaum SG, Scharfman HE, Eisch AJ, Hsieh J. Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline. Nat Commun. 2015 Mar 26;6:6606. doi: 10.1038/ncomms7606. PMID: 25808087; PMCID: PMC4375780.

  • Yu TS, Kim A, Kernie S.G. Donepezil rescues spatial learning and memory deficits following traumatic brain injury independent of its effects on neurogenesis. PLoS One. 2015 Feb 25;10(2):e0118793. doi: 10.1371/journal.pone.0118793. PMID: 25714524; PMCID: PMC4340948.

  • Sun C, Sun H, Wu S, Lee CC, Akamatsu Y, Wang RK, Kernie S.G., Liu J. Conditional ablation of neuroprogenitor cells in adult mice impedes recovery of poststroke cognitive function and reduces synaptic connectivity in the perforant pathway. J Neurosci. 2013 Oct 30;33(44):17314-25. doi: 10.1523/JNEUROSCI.2129-13.2013. PMID: 24174664; PMCID: PMC3812503.

  • Chen J, Li Y, Yu TS, McKay RM, Burns DK, Kernie S.G., Parada LF. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature. 2012 Aug 23;488(7412):522-6. doi: 10.1038/nature11287. PMID: 22854781; PMCID: PMC3427400.

  • Weng, Q., Chen, Y., Wang, H., Xu, X., Yang, B., He, Q., Shou, W., Chen, Y., Higashi, Y., ven den Berghe, V., Seuntjens, E., Kernie, S.G., Bukshpun, P., Sherr, E. H., Huylebroeck, D., and Lu, Q.R. (2012) Dual-mode modulation of Smad signaling by Smad-Interacting protein Sip1 is required for myelination in the central nervous system. Neuron. 73 (4): 713-728. doi: 10.1016/j.neuron.2011.12.021. PMID: 22365546; PMCID: PMC3293152.

  • Goto J, Talos DM, Klein P, Qin W, Chekaluk YI, Anderl S, Malinowska IA, Di Nardo A, Bronson RT, Chan JA, Vinters HV, Kernie S.G., Jensen FE, Sahin M, Kwiatkowski DJ. Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):E1070-9. doi: 10.1073/pnas.1106454108. Epub 2011 Oct 24. PMID: 22025691; PMCID: PMC3214999.

  • Gilley JA, Kernie S.G. Excitatory amino acid transporter 2 and excitatory amino acid transporter 1 negatively regulate calcium-dependent proliferation of hippocampal neural progenitor cells and are persistently upregulated after injury. Eur J Neurosci. 2011 Dec;34(11):1712-23. doi: 10.1111/j.1460-9568.2011.07888.x. Epub 2011 Nov 17. PMID: 22092549; PMCID: PMC4390033.

  • Yang CP, Gilley JA, Zhang G, Kernie S.G. ApoE is required for maintenance of the dentate gyrus neural progenitor pool. Development. 2011 Oct;138(20):4351-62. doi: 10.1242/dev.065540. Epub 2011 Aug 31. PMID: 21880781; PMCID: PMC3177307.

  • Blaiss CA, Yu TS, Zhang G, Chen J, Dimchev G, Parada LF, Powell CM, Kernie S.G. Temporally specified genetic ablation of neurogenesis impairs cognitive recovery after traumatic brain injury. J Neurosci. 2011 Mar 30;31(13):4906-16. doi: 10.1523/JNEUROSCI.5265-10.2011. PMID: 21451029; PMCID: PMC3103868.

  • Gilley JA, Yang CP, Kernie S.G. Developmental profiling of postnatal dentate gyrus progenitors provides evidence for dynamic cell-autonomous regulation. Hippocampus. 2011 Jan;21(1):33-47. doi: 10.1002/hipo.20719. PMID: 20014381; PMCID: PMC2895957.

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