Research Projects

We are currently pursuing several major interest areas:

  • Ascertaining the difference between kinase deletion vs kinases inhibition by understanding the structural function of ATM, ATR and DNA-PKcs in vivo
  • Identifying novel players of the NHEJ pathway and their roles in primary immunodeficiency
  • Dissecting how chromatin-bound DNA damage response factors promote chromosomal end-ligation and limit end-resection and chromosomal translocations
  • Elucidating the mechanisms by which pathogenic chromosome translocations elicit human lymphoid malignancies and generating new mouse models of these diseases, and most recently
  • Understanding the PARylation-dependent regulation of the poly-[ADP-ribose] polymerases (PARPs) during DNA repair
  • Understand the scars of cancer therapy and the molecular mechanism of therapy induced AML