Research Projects

A Prospective Study Examining the Role of Gestational SSRI Exposure in the Development of Functional Gastrointestinal Disorders

  • Funding: NIH R01
  • Principal Investigators: Margolis/Savidge/Talati/Takser

A Longitudinal Study Assessing a Multi-Intervention Approach in Children with Autism Spectrum Disorders

  • Funding: The Kirby Kulkan Family
  • Principal Investigator: Kara Gross-Margolis, MD

Defining the Role of the 5-HT4 Receptor in the Brain, Behavior, and Gut Abnormalities Resulting From In Utero SSRI Exposure

The goals of this study are to elucidate the ways in which the 5-HT4 receptor modulates the brain and intestinal anomalies that can result from antenatal antidepressant exposure

  • Funding: Department of Defense PR160365
  • Principal Investigators: Kara Gross-Margolis, MD/Mark Ansorge, PhD

Microenvironment in Enteric Neuron Development

We will evaluate the hypothesis that defects that arise due to serotonergic or cholinergic signaling in ontogeny, due to environmental perturbations, contribute to dysmotility in adults.

  • Funding: NIH NINDS R01
  • Principal Investigators: Kara Gross-Margolis, MD/Michael Gershon, MD

Linkage of s100a10 (p11) to Enteric 5-HT4-Mediated Serotonergic Signaling Roles in GI Motility, Enteric Nervous System Development, and Co-Morbid Dysfunction of Gut and Brain

  • Funding: NIH R01
  • Principal Investigator: Kara Gross-Margolis, MD