Clinical Trials

  • Congenital Anomalies Research Exploration - CARE study

    CARE is a new research initiative that aims to investigate the underlying genetic causes of various birth defects. By identifying the cause of these defects, we hope to be able to better understand their natural history which may ultimately lead to better treatment and management. Knowing the genetic causes of birth defects also allows us to assess the hereditary risk of the defect in a family. The study is free and involves submission of a blood or saliva sample from a child with a birth defect and both parents.

  • Database of Pediatric Hematology, Oncology, and Stem Cell Transplant Patients Tested for COVID-19 in the Tri-State Area

    Principal Investigator

    Prakash Satwani, MD
    The COVID-19 Hematology, Oncology, Stem Cell Transplant (HOT) Consortium of Greater New York City is trying to learn more about the effects of COVID-19 on hemoglobinopathies, immunodeficiencies and cancer in children and young adults.

  • DHREAMS: A genetic study of congenital diaphragmatic hernia (CDH).

    Each year more than 1,000 babies in the United States are born with a Congential Diaphragmatic Hernia (CDH). For the majority of these babies, the cause of the CDH is unknown. DHREAMS (Diaphragmatic Hernia Research & Exploration; Advancing Molecular Science) study was created to improve the understanding of the molecular genetic basis of CDH. This National Institute of Health (NIH)-funded research team is composed of health care providers and researchers across the country, coordinated at Columbia University Medical Center.

  • Early Developmental Changes, Risk for Diabetes, and the Microbiome in Children

    We are recruiting boys between 3-9 years old and girls between 3-8 years old to participate in a research study. Children who would like to participate must be healthy and not showing signs of puberty. The goal of the study is to understand the relationship between early body development, metabolism (sugars and fats processing), and the saliva microbiome (bacteria that normally live inside the body). The study is performed in the morning after an overnight fast and may be completed in less than 2 hours.

  • Early Developmental Changes, Risk for Diabetes, and the Microbiome in Children

    We are recruiting boys between 3-9 years old and girls between 3-8 years old to participate in a research study. Children who would like to participate must be healthy and not showing signs of puberty. The goal of the study is to understand the relationship between early body development, metabolism (sugars and fats processing), and the saliva microbiome (bacteria that normally live inside the body). The study is performed in the morning after an overnight fast and may be completed in less than 2 hours.

  • Effects of varying bubble nasal continuous airway pressure in very low birth weight infants

    Principal Investigator

    Rakesh Sahni, MBBS
    The purpose of this study is to see if the use of bubble nasal continuous positive airway pressure (NCPAP) at a pressure of 6-7 centimeters of water (cm H2O) in very low birth weight (VLBW) infants is associated with improved gas exchange without any related changes in vital signs.

  • Eribulin Mesylate in Pediatric Subjects with Rhabdomyosarcoma (RMS), non-Rhabdomyosarcoma Soft Tissue Sarcoma(NRSTS) and Ewing Sarcoma(EWS)

    The main purpose of this study is to see if eribulin might work and might be used in the treatment of pediatric subjects with rhabdomyosarcoma (RMS), non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) and Ewing sarcoma (EWS) that has either come back or has not responded to the standard therapy. Eribulin will be administered as an intravenous (IV) infusion on Days 1 and 8 of each 21-day cycle.

  • FAST TRIAL REGISTRY

    Although supraventricular tachycardia (SVT), including atrial flutter (AF), are the most common causes of intended in-utero fetal therapy, none of the medication used to date has been evaluated for their effects on the mother and her baby in a randomized controlled clinical trial (RCT). In the absence of such evidence, there is no consensus for the optimal management. The purpose of the FAST Research study is to improve the care of pregnancies affected by AF or SVT.

  • Fetal Atrial Flutter & Supraventricular Tachycardia (FAST) Therapy Trial

    The purpose of the study is to clarify the best treatment for your babys condition by looking at how well the medicine worked to bring your babys heart rate back to normal and if you experienced any side-effects from the treatment. You are being asked to take part in a research study because your fetus has been diagnosed with a fast heart rate.

  • Genetic Analysis of Obesity and Type 2 Diabetes Mellitus

    Principal Investigator

    Wendy K. Chung, MD, PhD
    This study is designed to determine the role of specific genes in obesity and/or type 2 diabetes mellitus. Patients who are severely obese, and/or with an onset of type 2 diabetes at less than 25 years of age. Ideally, we would like to have families involved in this study. The ideal family is one in which NOT everyone in the family is obese or diabetic. Families in which one or neither parent is obese/diabetic, and some but not all children are obese/diabetic, are ideal.

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