Clinical Trials
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Principal Investigator:
Steven J. Lobritto, MDIn this study, we will collect information from the medical record of pediatric liver transplant recipients who received live vaccines as part of their routine post-transplant care. This data will be combined with data from other centers across the United States and Canada to help give us a better understanding of the safety and efficacy of live vaccines in the patient population. Vaccine-preventable illness continues to have resurgence in the United States and globally. Specifically, mumps and measles outbreaks have occurred with increasing frequency and distribution in the past several... -
Principal Investigator:
Steven J. Lobritto, MDIn this study, we will collect information from the medical record of pediatric liver transplant recipients who received live vaccines as part of their routine post-transplant care. This data will be combined with data from other centers across the United States and Canada to help give us a better understanding of the safety and efficacy of live vaccines in the patient population. Vaccine-preventable illness continues to have resurgence in the United States and globally. Specifically, mumps and measles outbreaks have occurred with increasing frequency and distribution in the past several... -
Principal Investigator:
Mercedes Martinez, MDThe purpose of this study is to determine whether the investigational drug (maralixibat) is safe and effective in children and participants who have cholestatic liver disease with pruritus (itch) that has been responding to other therapies, and who have no other treatment options.If you have any questions regarding this study, please contact the Transplant Clinical Research Center (TCRC). -
Principal Investigator:
Mercedes Martinez, MDThis study is examining how oral vancomycin, an antibiotic sometimes used to treat Primary Sclerosing Cholangitis (PSC), affects the bacteria living in the gut (the microbiome). The study is observational, meaning it does not alter medical care or prescribe treatment-participants will continue their usual therapy as decided by their doctors. The study will last about six months per participant and involves three study visits for stool collection and questionnaires, which may be completed in person or remotely. This research may help uncover how gut bacteria influence PSC and lead to better... -
Principal Investigator:
Nobuko Hijiya, MDThis study is called a screening study and the purpose of this study to find better ways to diagnose and treat leukemia that has come back after treatment or difficult to treat. Bone marrow, blood, and medical information about cancer and treatment will be collected. The results from this screening study may give other information about leukemia that is important when deciding how to best treat leukemia. -
Principal Investigator:
Nobuko Hijiya, MDThis study is called a screening study and the purpose of this study to find better ways to diagnose and treat leukemia that has come back after treatment or difficult to treat. Bone marrow, blood, and medical information about cancer and treatment will be collected. The results from this screening study may give other information about leukemia that is important when deciding how to best treat leukemia. -
Principal Investigator:
Rudolph L. Leibel, MDThe Physiology of the Weight Reduced State (POWERS) is a national research study designed to discover and learn what happens to the human body after weight loss and to learn why some people regain their lost weight. Understanding why this happens could help health professionals improve strategies for successful weight loss maintenance after weight loss. POWERS is a research study with a goal to understand the changes in the body that occur after weight loss and learn how these changes affect the ability to keep the weight off. It involves universities, medical centers, researchers, and most... -
Principal Investigator:
Ilene Fennoy, MDWe are doing this research study to find out what happens to children who are overweight and how the things we recommend as a part of routine clinical care affect your child. The purpose of this study is to understand what happens to children as a result of being overweight, to link these outcomes to specific clinical measures, and to determine how treatment affects the physical and clinical features of overweight or obesity. To achieve this aim we want to formalize our ongoing clinical chart review into a database for our patients. -
Principal Investigator:
Mercedes Martinez, MDThis study is evaluating how well odevixibat, an approved medication for Alagille Syndrome (ALGS), works in real-world clinical practice and how safe it is for long-term use. Participants with ALGS who are receiving odevixibat as part of their usual medical care will be followed for about five years. During this time, information from routine clinic visits will be collected to understand how treatment affects liver health, growth, and development, and to identify any side effects. This research may help improve care and future treatment options for people living with ALGS. If you have any... -
Principal Investigator:
Melissa S. Stockwell, MD, MPHHelp us to better understand the long term effects of COVID. If you or your child has had COVID, or is feeling the long term effects of COVID, you might be able to help us understand more about it and treat it. Even if you or your child has never had COVID, you might be able to help. We are seeking volunteers who are under 25 to join the NIH RECOVER initiative. Once someone is enrolled, they will fill out a survey for us and take a home blood test. Then about half of people will be asked if they want to continue in the study to take some more surveys and come to themedical center for some...