Department of Pediatrics Annual Report – 2020
Allergy, Immunology, and Rheumatology
Unraveling the enigma of immune disease and allergic disorders
The past three years have been transformative for the Division of Allergy, Immunology, and Rheumatology. Following the appointment of immunologist Jordan Orange, MD, PhD, as department chair in 2018, Joshua Milner, MD, was named division chief in 2019 and Ramsay Fuleihan, MD, joined as clinical director in 2020. The division now includes some of the best-known names in the care of children with allergy, immune-related, or autoimmune-related diseases. These leaders in the field have created new laboratories and research programs while providing expert diagnoses and care to children and families, many of whom have long sought an identification of a chronic illness.
NewYork-Presbyterian Morgan Stanley Children’s Hospital now serves as a referral center for other children’s hospitals and has the expertise and resources to diagnose and care for the most complex patients. Our physicians share their knowledge as chairs of numerous national committees, create and participate in patient registries, author numerous publications, and participate on editorial and scientific advisory boards.
Clinical Services
We provide consultative inpatient and outpatient expertise for initial diagnoses, second opinions, immunologic and autoimmune testing, and genetic testing, as well as expert medical care.
Allergy and Immunology
- We offer the latest diagnostic and treatment options for food allergies and are committed to developing new therapeutics and best practices
- Through our NYS Severe Combined Immunodeficiency (SCID) Program newborn screening program, we identify newborns with SCID at the earliest possible moment
- Members of our specialized program in primary immunodeficiency use state-of-the-art measures to diagnose and treat infants and children with congenital immunodeficiencies
- The Natural Killer Cell Evaluation and Research Clinic (NEAR) offers diagnosis, evaluation, testing, and access to research studies for infants, children, and adults with suspected natural killer (NK) cell deficiency diseases and other primary immunodeficiency diseases
- Division members have special clinical and research interests in primary atopic disorders and other genetic diseases that lead to allergy or immune dysregulation
- In collaboration with Columbia’s Institute for Genomic Medicine, the division’s immunogenetics program brings together leading scientific and clinical perspectives to end the diagnostic odyssey for those struggling with immune disease
- In 2020 Columbia was designated one of the few Jeffrey Modell Diagnostic and Research Centers globally. Dr. Joshua Milner serves as director
Rheumatology
Our rheumatology team cares for children with a full range of rheumatic and autoimmune diseases and collaboratively cares for patients with the most complex conditions. Through our specialized program in pediatric amplified musculoskeletal pain syndrome, we develop individualized, comprehensive, and patient-centered treatment plans for children and adolescents with chronic musculoskeletal pain conditions.
Research
The division is involved in several areas of research and participates in clinical trials, most actively in the causes, mechanisms, and treatment of asthma, allergies, food allergies, juvenile arthritis, and primary immune deficiencies. Our program is also one of the few funded research programs in Kawasaki disease. Investigators in our program have received support from the National Institutes of Health and other organizations for more than two decades and publish in journals including New England Journal of Medicine, Nature, The Journal of the American Medical Association, The Lancet, Up-to-Date, Journal of Allergy and Clinical Immunology, and Journal of Clinical Investigation.
Education
We offer outstanding training in allergy, immunology, and rheumatology to fellows, residents, and medical students. The Allergy and Immunology Fellowship leads to certification by the American Board of Allergy & Immunology.
New Appointments
- Joshua Milner, MD, Director, Division of Pediatric Allergy, Immunology, and Rheumatology, Chief, Allergy, Immunology, and Rheumatology Services New York-Presbyterian Morgan Stanley Children’s Hospital
- Mark Gorelik, MD, Assistant Professor of Pediatrics
- Ramsay Fuleihan, MD, Professor of Pediatrics, Clinical Director, Pediatric Allergy, Immunology, and Rheumatology
Honors and Awards
Anu Mallapaty, MD
- Accepted to the ACAAI Leadership Summit, 2020
Emily Mace, PhD
- Schaefer Scholar Award, 2020
- Elected to the Henry Kunkel Society, 2020
Jordan Orange, MD, PhD
- CIS Distinguished Service Award, 2020
- Elected to National Academy of Medicine, 2018
Joshua Milner, MD
- Society for Pediatric Research – E. Mead Johnson Award for Research Achievement in Pediatrics, 2019
Mark Gorelik, MD
- AAAAI Foundation Faculty Development Award, The American Academy of Allergy, Asthma & Immunology Foundation, 2020
Major Grants
- Exacerbated expression of cytotoxic genes in the PLNs of T1D patients. Leona Helmsley Charitable Trust; UMIAMI CU19-0311 (PI: Creusot); Principal Investigator: Emily Mace, PhD.
- Defining the role of cell migration in human NK cell differentiation. NIH/National Institute of Allergy and Infectious Diseases; R01 AI137073-01; Principal Investigator: Emily Mace, PhD.
- Determining the role of the replicative helicase in human NK cell development. NIH/National Institute of Allergy and Infectious Diseases; R01AI137275-01; Principal Investigator: Emily Mace, PhD.
- New York State Stem Cell Science – Columbia Training Program in Stem Cell Research (Recipient: postdoctoral fellow Seungmae Seo, PhD); (PI: Vunjak-Novakovic) OH01-C30291GG-3450000; Principal Investigator: Emily Mace, PhD.
- Shire; New York City Primary immunodeficiency and immune dysregulation consortium; IME-23946; Principal Investigator: Emily Mace, PhD.
- NY FIRST, Empire State Development Corporation; Principal Investigator: Jordan Orange, MD, PhD.
- Directing function at the natural killer cell secretory immunological synapse, NIH/National Institute of Allergy and Infectious Diseases; R01AI067946-14; Principal Investigator: Jordan Orange, MD, PhD.
- Genetic, immunologic and mechanistic basis of human NK cell deficiency, NIH/National Institute of Allergy and Infectious Diseases; R01AI120989-06; Principal Investigator: Jordan Orange, MD, PhD.
- The AAAAI Foundation & Richard F. Lockey, MD, MS, FAAAAI & USF A/I Program Faculty Development Award; Principal Investigator: Mark Gorelik, MD.
- The role of fibroblast specific STAT3 expression in pneumatocele development and gastrointestinal perforation in AD-HIES. Job Research Foundation. Principal Investigator: Mark Gorelik, MD.
Selected Publications
Mace EM, Paust S, Conte MI, Baxley RM, Schmit MD, Patil SL, Guilz NC, Mukherjee M, Pezzi AE, Chmielowiec J, Tatineni S, Chinn IK, Akdemir ZC, Jhangiani SN, Muzny DM, Stray-Pedersen A, Bradley RE, Moody M, Connor PP, Heaps AG, Steward C, Banerjee PP, Gibbs RA, Borowiak M, Lupski JR, Jolles S, Bielinsky AK, Orange JS. Human NK cell deficiency as a result of biallelic mutations in MCM10. J Clin Invest. 2020 Oct 1; 130(10): 5272-5286. doi: 10.1172/JCI134966.
Spencer S, Köstel Bal S, Egner W, Lango Allen H, Raza SI, Ma CA, Gürel M, Zhang Y, Sun G, Sabroe RA, Greene D, Rae W, Shahin T, Kania K, Ardy RC, Thian M, Staples E, Pecchia-Bekkum A, Worrall WPM, Stephens J, Brown M, Tuna S, York M, Shackley F, Kerrin D, Sargur R, Condliffe A, Tipu HN, Kuehn HS, Rosenzweig SD, Turro E, Tavaré S, Thrasher AJ, Jodrell DI, Smith KGC, Boztug K, Milner JD, Thaventhiran JED. Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses. J Exp Med. 2019 Jun 24.
Lam, MT, Mace, EM, Orange, JS. A research-driven approach to the identification of novel natural killer cell deficiencies affecting cytotoxic function. Blood. 2002 Feb 27; 135(9): 629-637. doi: 10.1182/blood.2019000925.
Orange JS. How I nanage natural killer cell deficiency. J Clin Immunol Actions. 2020 Epub 2019, Nov 22 Jan; 40(1): 13-23. doi: 10.1007/s10875-019-00711-7.
Gunesch JT, Angelo LS, Mahapatra S, Deering RP, Kowalko JE, Sleiman P, Tobias JW, Monaco-Shawver L, Orange JS, Mace EM. Genome-wide analyses and functional profiling of human NK cell lines. Mol Imm. 2018. doi.org/10.1016/j.molimm.2018.07.015.
Mace EM, Orange JS. Emerging insights into human health and NK cell biology from the study of NK cell deficiencies. Immunol Rev. 2019 Jan; 287(1): 202-225. doi: 10.1111/imr.12725. Review. PubMed PMID: 30565241; PubMed Central PMCID: PMC6310041.
Gorelik M, Lee Y, Abe M, Andrews T, Davis L, Patterson J, Chen S, Crother TR, Aune GJ, Noval Rivas M, Arditi M. IL-1 receptor antagonist, anakinra, prevents dysfunction in a mouse model of Kawasaki disease vasculitis. Clin Exp Immunol. 2019 Oct; 198(1): 101-110.
Cheung EW, Zachariah P, Gorelik M, et al. Multisystem inflammatory syndrome related to COVID-19 in previously healthy children and adolescents in New York City. JAMA. Published online: 2020 June 08. doi:10.1001/jama.2020.10374.
Eisenberg R, Gans MD, Leahy TR, Gothe F, Perry C, Raffeld M, Xi L, Blackstone S, Ma C, Hambleton S, Milner JD. JAK inhibition in early-onset somatic, nonclonal STAT5B gain-of-function disease. J Allergy Clin Immunol Pract. 2020 Dec 5.
Milner JD. Primary Atopic Disorders. Annu Rev Immunol. 2020 Apr 26; 38: 785-808.
Highlights
Joshua Milner, MD, to Lead Pediatric Allergy, Immunology, and Rheumatology at Columbia, NewYork-Presbyterian
Joshua Milner, MD, an internationally renowned physician-scientist from the National Institutes of Health (NIH) whose research has uncovered the genetic underpinnings of allergic diseases in children, has been named chief of the Division of Allergy, Immunology, and Rheumatology in the Department of Pediatrics at Columbia University Vagelos College of Physicians and Surgeons and professor of pediatrics in the Institute for Genomic Medicine at Columbia University Irving Medical Center.
Andrea Califano and Jordan Orange Elected to National Academy of Medicine
Andrea Califano, Dr., and Jordan Orange, MD, PhD, of Columbia University Vagelos College of Physicians and Surgeons have been elected to the National Academy of Medicine(link is external and opens in a new window) for their contributions to medical science, health care, and public health.